Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Methyl 2-Methoxycarbonyl-3-Phenylpropionate Derivatives: A New Type of Angiotensin Converting Enzyme Inhibitors

Author(s): Hui Guo, Bing Xie and Xiao-Hua Cai

Volume 3, Issue 6, 2006

Page: [492 - 494] Pages: 3

DOI: 10.2174/157017806777828484

Price: $65

Abstract

Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. The inhibitiory activity of methyl 3-{4-[2- [N-(4-methylbenzylphenyl)methyl,N-methylamino]ethoxy]phenyl} -2-methoxycarbonylpropionate (5b, IC50 = 0.0039 μM) and methyl 3-{4-[2-[N-bis(4-methoxy phenyl)methyl,N-methylamino]ethoxy]phenyl}-2- methoxycarbonylpropionate (5d, IC50 = 0.0027 μM) was higher than that of control drug captopril (IC50 = 0.0075 μM).

Keywords: ACE inhibitor, 2-methoxycarbonyl-3-phenyl propionate derivative, Hypertension

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy