Methyl 2-Methoxycarbonyl-3-Phenylpropionate Derivatives: A New Type of Angiotensin Converting Enzyme Inhibitors

Author(s): Hui Guo , Bing Xie , Xiao-Hua Cai .

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 6 , 2006

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Abstract:

Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. The inhibitiory activity of methyl 3-{4-[2- [N-(4-methylbenzylphenyl)methyl,N-methylamino]ethoxy]phenyl} -2-methoxycarbonylpropionate (5b, IC50 = 0.0039 μM) and methyl 3-{4-[2-[N-bis(4-methoxy phenyl)methyl,N-methylamino]ethoxy]phenyl}-2- methoxycarbonylpropionate (5d, IC50 = 0.0027 μM) was higher than that of control drug captopril (IC50 = 0.0075 μM).

Keywords: ACE inhibitor, 2-methoxycarbonyl-3-phenyl propionate derivative, Hypertension

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2006
Page: [492 - 494]
Pages: 3
DOI: 10.2174/157017806777828484
Price: $58

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