Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Biological Evaluation of Coumarin Linked Fluoroquinolones, Phthalimides and Naphthalimides as Potential DNA Gyrase Inhibitors

Author(s): A. Kamal, M. Satyanarayana, V. Devaiah, V. Rohini, J. S. Yadav, B. Mullick, V. Nagaraja.


A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.

Keywords: Coumarins, Phthalimides, Naphthalimides and Fluoroquinolone DNA gyrase inhibition

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Article Details

Year: 2006
Page: [494 - 502]
Pages: 9
DOI: 10.2174/157018006778194862
Price: $58