Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis
W. J. Burke,
S. W. Li,
K. N. Gillespie,
H. D. Chung,
J. H. Joist.
Free radical damage to endothelial cells is implicated in the pathogenesis of arteriosclerosis. We show that platelet monoamine oxidase (MAO) synthesizes 3,4-dihydroxyphenylglycolaldeyde (DOPEGAL), the free radical generating metabolite of norepinephrine (NE). Platelet synthesis of DOPEGAL could contribute to arteriosclerosis and provide a target for protective therapy to prevent arteriosclerosis in medical conditions with elevated NE levels.
Keywords: 3,4-dihydroxyphenylglycolaldehyde, Free radicals, Arteriosclerosis, Platelets, Monoamine oxidase
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