Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis

Author(s): W. J. Burke, S. W. Li, K. N. Gillespie, H. D. Chung, K. Jagadeesan, J. H. Joist.

Abstract:

Free radical damage to endothelial cells is implicated in the pathogenesis of arteriosclerosis. We show that platelet monoamine oxidase (MAO) synthesizes 3,4-dihydroxyphenylglycolaldeyde (DOPEGAL), the free radical generating metabolite of norepinephrine (NE). Platelet synthesis of DOPEGAL could contribute to arteriosclerosis and provide a target for protective therapy to prevent arteriosclerosis in medical conditions with elevated NE levels.

Keywords: 3,4-dihydroxyphenylglycolaldehyde, Free radicals, Arteriosclerosis, Platelets, Monoamine oxidase

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Article Details

VOLUME: 3
ISSUE: 7
Year: 2006
Page: [481 - 487]
Pages: 7
DOI: 10.2174/157018006778194880
Price: $58