Synthesis and Biological Evaluation of Spirostanes Including Butyrolactone Moieties

Author(s): Carlos S. Perez, Vivian Leliebre-Lara, Odette Concepcion, Francisco Coll, Daniel G. Rivera, Orlando Pando.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 7 , 2006

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Abstract:

Four new spirostanes functionalized with the butyrolactone moiety were efficiently synthesized and submitted to preliminary biological tests. Two practical synthetic routes were designed to enable the incorporation of the γ-lactone functionality into rings A and B. Butyrolactones 5 and 10 showed a promising plant growth-promoting activity which renders them good candidates for further biological studies.

Keywords: butyrolactones, biological activity, steroidal sapogenins, Steroids

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Article Details

VOLUME: 3
ISSUE: 7
Year: 2006
Page: [519 - 522]
Pages: 4
DOI: 10.2174/157017806778341870
Price: $58

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