Synthesis and Biological Evaluation of Spirostanes Including Butyrolactone Moieties

Title: Synthesis and Biological Evaluation of Spirostanes Including Butyrolactone Moieties

Volume: 3 Issue: 7

Author(s): Carlos S. Perez, Vivian Leliebre-Lara, Odette Concepcion, Francisco Coll, Daniel G. Rivera and Orlando Pando

Affiliation:

Keywords: butyrolactones, biological activity, steroidal sapogenins, Steroids

Abstract: Four new spirostanes functionalized with the butyrolactone moiety were efficiently synthesized and submitted to preliminary biological tests. Two practical synthetic routes were designed to enable the incorporation of the γ-lactone functionality into rings A and B. Butyrolactones 5 and 10 showed a promising plant growth-promoting activity which renders them good candidates for further biological studies.

Cite this article as:

Perez S. Carlos, Leliebre-Lara Vivian, Concepcion Odette, Coll Francisco, Rivera G. Daniel and Pando Orlando, Synthesis and Biological Evaluation of Spirostanes Including Butyrolactone Moieties, Letters in Organic Chemistry 2006; 3 (7) . https://dx.doi.org/10.2174/157017806778341870