Oxepin- and Spiro-Annulation of 2-Pyridone in Conjunction with Claisen Rearrangement and Ruthenium Carbene Complex Mediated Enyne Metathesis (SUPPORTING DATA)

Author(s): Brindaban Roy, Krishna C. Majumdar, Habibur Rahaman.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 7 , 2006

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Abstract:

A direct synthesis of substituted oxepin and spiroheterocycles has been achieved from substrates derived from 4-hydroxy-1,6-dimethyl pyridine-2-ones (1) by combining Claisen rearrangement and ring closing enyne metathesis. The RCEM proceeded smoothly under nitrogen atmosphere at room temperature in the presence of well-defined ruthenium catalyst A (10 mol%).

Keywords: 2-Pyridone, oxepin, ring-closing metathesis, Claisen rearrangement, enyne metathesis

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Article Details

VOLUME: 3
ISSUE: 7
Year: 2006
Page: [526 - 529]
Pages: 4
DOI: 10.2174/157017806778341816
Price: $58

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