An Efficient Synthesis of 3-Benzyl-2H-Chromenes as Potential Antipicornavirus Agents

Author(s): Nicoletta Desideri.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 7 , 2006

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The 3-benzyl-2H-chromenes (3 a-d), designed as potential inhibitors of picornavirus infections, were synthesized by a simple and convenient three-step procedure starting from the O-alkylation of the appropriate 2-(hydroxymethyl)phenols with 1-bromo-3-phenylpropan-2-ones. The resulting ethers (1 a-d) were converted to the corresponding triphenylphosphonium bromides (2 a-d) and finally cyclized by an intramolecular Wittig reaction.

Keywords: 3-Benzyl-2H-chromenes, flavanoids, antipicornavirus agents

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Article Details

Year: 2006
Page: [546 - 548]
Pages: 3
DOI: 10.2174/157017806778341915
Price: $58

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