Access to Chiral N-Substituted 1,4-Dihydropyridines Through the One-Pot Domino Michael-Azacyclization Process

Author(s): N. Monnier-Benoit, I. Jabin, P. Netchitailo.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 7 , 2006

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The one-pot domino Michael-azacyclization process was applied to the synthesis of chiral Nsubstituted 1,4-dihydropyridines. Chiral enaminoesters were reacted with alkylidene malonate olefins or α,β- ethylenic aldehydes. The crucial role of the α-substituent of the starting enaminoester both on the diastereoselectivity and on the orientation of the reaction was clearly evidenced.

Keywords: 1,4-dihydropyridines, aza-Michael, enaminoesters

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Article Details

Year: 2006
Page: [549 - 553]
Pages: 5
DOI: 10.2174/157017806778341834
Price: $58

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