Access to Chiral N-Substituted 1,4-Dihydropyridines Through the One-Pot Domino Michael-Azacyclization Process

Author(s): N. Monnier-Benoit, I. Jabin, P. Netchitailo.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 7 , 2006

Become EABM
Become Reviewer

Abstract:

The one-pot domino Michael-azacyclization process was applied to the synthesis of chiral Nsubstituted 1,4-dihydropyridines. Chiral enaminoesters were reacted with alkylidene malonate olefins or α,β- ethylenic aldehydes. The crucial role of the α-substituent of the starting enaminoester both on the diastereoselectivity and on the orientation of the reaction was clearly evidenced.

Keywords: 1,4-dihydropyridines, aza-Michael, enaminoesters

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 3
ISSUE: 7
Year: 2006
Page: [549 - 553]
Pages: 5
DOI: 10.2174/157017806778341834
Price: $58

Article Metrics

PDF: 5