Recent Patents on Anti-Infective Drug Discovery

Dieter Kabelitz  
Institute of Immunology
Universitätsklinikum Schleswig-Holstein
Campus Kiel


Review of Airway Illnesses by Kytococcus and Rothia and a Look at Inhalatory Vancomycin as a Treatment Support

Author(s): Vincenzo Savini, Chiara Catavitello, Gioviana Masciarelli, Daniela Astolfi, Andrea Balbinot, Azaira Bianco, Fabio Febbo, Claudio D'Amario and Domenico D'Antonio

Affiliation: Clinical Microbiology and Virology, Department of Transfusion Medicine, Spirito Santo Hospital, via Fonte Romana 8, CAP 65100, Pescara (Pe), Italy.


Seriously compromised patients may acquire deep airway ailments by Gram positive, commensal bacteria including Kytococcus and Rothia, pathogenic tracts of which still remain quite unexplored. Resistances they express have been poorly investigated over the years, and no published guidelines for susceptibility testing and antibiotic therapy exist. We would therefore revise the current knowledge about these opportunistic organisms clinical impact, as well as discuss on recent patents focusing on lung infection management. Particularly, these deal with the use of inhalatory vancomycin, even as lipidic complex, that appears a promising adjunctive treatment to systemic antimicrobials.

Keywords: Kytococcus, Rothia, pneumonia, airway, lung, bronchitis, vancomycin, aerosol, liposome, Gram positive, saprophyte, Micrococcaceae, Actinomycetales, Micrococcus sedentarius, Kytococcus schroeteri, rRNA, DNA, K. sedentarius, Rothia dentocariosa, Actinomyces dentocariosus, Nocardia dentocariosa, Nocardia salivae, Actinomyces, Rothia aeria, R. dentocariosa, Kocuria kristinae, Vitek2 ID-GP, isoxazolyl penicillins, oxacillin, cloxacillin, flucloxacillin, Staphylococcus, R. mucilaginosa, Clostridium difficile, pseudomembranous colitis

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Article Details

Page: [64 - 71]
Pages: 8
DOI: 10.2174/157489111794407822