Convergent Synthetic Studies Towards the Ribosyl-Diazepanone Core of the Liposidomycins

Author(s): Christine Greck, Bruno Drouillat, Yann Bourdreux.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 5 , 2006

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Abstract:

New types of ribosyl-diazepanone derivatives of nucleoside antibiotic liposidomycins, 12a and 12b, have been synthesised. The ribosyl 7-membered heterocycles were formed by reductive amination of the α-ribosylamino acid 9 derived from D-ribose and the amino aldehydes 10a or 10b, followed by a peptidic coupling reaction.

Keywords: ribosylamino acid, liposidomycin, lactamisation, diazepanone, Antibiotic

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2006
Page: [368 - 370]
Pages: 3
DOI: 10.2174/157017806776611827
Price: $65

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