Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones

Author(s): Chanaz Salmi, Yves Letourneux, Jean M. Brunel.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 5 , 2006

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Abstract:

An efficient method for the diastereoselective synthesis of various secondary amines through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and (R)-Phenylethylamine were involved leading to the expected products in moderate to excellent yields and importantly in diastereoselectivities up to 100% in one case.

Keywords: Titanium, Reductive amination, Ketones, Secondary amines, Imines, Diastereoselectivity

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2006
Page: [384 - 389]
Pages: 6
DOI: 10.2174/157017806776611971
Price: $65

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