Synthesis of C1-C6 Fragment of Caribenolide I

Author(s): Matar Seck, Blandine Seon-Meniel, Jean-Christophe Jullian, Xavier Franck, Reynald Hocquemiller, Bruno Figadere.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 5 , 2006

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Abstract:

Stereoselective synthesis of C1-C6 fragment of caribenolide I, a potent antitumour macrolide isolated from a marine dinoflagellate Amphidinium sp. is described. The key step relies on an asymmetric aldol reaction for control the absolute configurations of C2 and C3 stereogenic centers (caribenolide I numbering).

Keywords: Amphidinolide, macrolide, antitumor, cytotoxic activity, aldolisation, oxazolidinones, oxazolidin-2-thiones

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2006
Page: [390 - 395]
Pages: 6
DOI: 10.2174/157017806776611818
Price: $65

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