Stereoselective synthesis of C1-C6 fragment of caribenolide I, a potent antitumour macrolide isolated from a marine dinoflagellate Amphidinium sp. is described. The key step relies on an asymmetric aldol reaction for control the absolute configurations of C2 and C3 stereogenic centers (caribenolide I numbering).
Keywords: Amphidinolide, macrolide, antitumor, cytotoxic activity, aldolisation, oxazolidinones, oxazolidin-2-thiones
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