Cyanosilylation of Hetero-Substituted Ketones Catalyzed by LiCl

Author(s): Takeshi Ohkuma, Nobuhito Kurono, Ken Suzuki.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 4 , 2006

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Abstract:

LiCl efficiently catalyzes cyanosilylation of various hetero-substituted ketones. α,α-Dialkoxy ketones are completely converted to silylated cyanohydrins with a substrate-to-catalyst molar ratio of 100,000 at room temperature. Acetophenones substituted by an electron-attracting group at the ortho or para position show higher reactivity than substrates with an electron-donating function.

Keywords: silylated cyanohydrins, lithium chloride, hetero-substituted ketones, cyanotrimethylsilane, cyanosilylation, Catalytic reaction

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2006
Page: [275 - 277]
Pages: 3
DOI: 10.2174/157017806776114658
Price: $65

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