A Silica-Supported Copper(I) Catalyzed Sonogashira Coupling Reaction

Author(s): Lei Wang, Pinhua Li, Liyuan Zhang.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 4 , 2006

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An immobilization of copper(I) in organic-inorganic hybrid materials catalyzed Sonogashira coupling reaction was developed. Terminal alkynes reacted with aryl iodides and aryl bromides in the presence of 3-(2-aminoethylamino)propyl functionalized silica gel immobilized copper(I) catalyst, triphenylphosphine and potassium carbonate in DMF. The reactions generated the corresponding cross-coupling products in good to excellent yields. Furthermore, silica-supported copper was recovered and recycled by a simple filtration of the reaction solution and used for six consecutive trials without decreases in activity.

Keywords: heterogeneous catalyst, immobilization of copper(I), organic-inorganic hybrid material, Sonogashira coupling reaction

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Article Details

Year: 2006
Page: [282 - 285]
Pages: 4
DOI: 10.2174/157017806776114559
Price: $65

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