A Radical Route to a cis-3,5-Dialkyl Proline Derivative

Author(s): Sebastien Guesne, Sebastien Comesse, Catherine Kadouri-Puchot.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 4 , 2006

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Abstract:

β-Amino alcohols possessing an alkynyl functionality were converted into bicyclic compounds via a 5-exo-dig radical cyclization. One of this bicyclic product was transformed in three steps into the (2R,3S,5S)- 3-methyl-5-iso-propyl proline.

Keywords: Amino alcohols, radical cyclization, proline derivative

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2006
Page: [315 - 316]
Pages: 2
DOI: 10.2174/157017806776114667
Price: $65

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