Highlights in Organic Chemistry Phase Vanishing" Method-System for Diffusion Controlled Addition of Exothermic Reagents Through a Fluorous Membrane

Author(s): Jernej Iskra.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 3 , 2006

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Abstract:

Fluorous solvent in "phase-vanishing" reactions acts as a phase screen between the bulk reagent and the reaction phase. The unique properties of the fluorous phase enable the slow diffusion-controlled transport of reagent through this bulk membrane and its uniform phase-transition from transport to reaction phase. Slow addition through the whole interface prevents the build-up of localised high concentration of reagent which means that it is possible to perform reactions involving highly reactive reagents at room temperature.

Keywords: Friedel-Crafts Acylation, Halodehydroxylation, Bromination, fluorous phase, organic solvent, F-compounds

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [170 - 175]
Pages: 6
DOI: 10.2174/157017806775789976
Price: $65

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