Fluorous solvent in "phase-vanishing" reactions acts as a phase screen between the bulk reagent and the reaction phase. The unique properties of the fluorous phase enable the slow diffusion-controlled transport of reagent through this bulk membrane and its uniform phase-transition from transport to reaction phase. Slow addition through the whole interface prevents the build-up of localised high concentration of reagent which means that it is possible to perform reactions involving highly reactive reagents at room temperature.
Keywords: Friedel-Crafts Acylation, Halodehydroxylation, Bromination, fluorous phase, organic solvent, F-compounds
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