Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols

Author(s): Thies Thiemann, G. Ribeiro M., Maria C. d. Neves Oliveira.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 3 , 2006

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Abstract:

A series of C7-substituted estra-1,3,5(10),6-tetraene-3,17β-diols were prepared as precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene- 3,17β-diols.

Keywords: thermal dehydration, conjugate addition, steroids, Estranes

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [214 - 219]
Pages: 6
DOI: 10.2174/157017806775789796
Price: $58

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