One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts

Author(s): Genxiang Luo, Chunsheng Liu, Haixia Zhou, Miao He.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 3 , 2006

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Abstract:

An improved approach has been found to carry out the Biginelli reaction for the synthesis of 3,4- dihydropyrimidin- 2(1H)-one derivatives. This synthesis was performed in the presence of hydrochloric acid and β-cyclodextrin in ethanol solution. Compared with the classical Biginelli reaction conditions, this new approach has the advantage of excellent yields and short reaction time.

Keywords: Biginelli reaction, Dihydropyrimidinones, β-cyclodextrin, One-pot, Synthesis

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2006
Page: [225 - 227]
Pages: 3
DOI: 10.2174/157017806775789985
Price: $65

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