An improved approach has been found to carry out the Biginelli reaction for the synthesis of 3,4- dihydropyrimidin- 2(1H)-one derivatives. This synthesis was performed in the presence of hydrochloric acid and β-cyclodextrin in ethanol solution. Compared with the classical Biginelli reaction conditions, this new approach has the advantage of excellent yields and short reaction time.
Keywords: Biginelli reaction, Dihydropyrimidinones, β-cyclodextrin, One-pot, Synthesis
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