Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7- trimethoxyindole-2-carboxamide (iso-CFI) Analogs of Duocarmycin C2: Synthesis and Biological Evaluation

Author(s): John A. Hartley, Moses Lee, Konstantinos Kiakos, Stephen Hudson, Heather Townes, Kaitlin Summerville, Adrienne Scott, Brian Lingerfelt, Bethany Purnell.

Journal Name: Medicinal Chemistry

Volume 2 , Issue 2 , 2006

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Abstract:

Racemic seco-iso-CFI (cyclopropylfurano[e]indoline) analogs of the duocarmycins and CC-1065 have recently been reported by our group. These compounds covalently react with AT-rich sequences of DNA, and they exhibit potent cytotoxicity against cancer cells but are less toxic to normal bone marrow cells. This article details the synthesis of enantiomerically pure (S)-(-)- and R-(+)-seco-iso-CFI (cyclopropylfurano[e]indoline)-5,6,7-trimethoxyindole-2- carboxamide analogs, (S)-(-)-1 and (R)-(+)-1, respectively. The covalent DNA binding properties and cytotoxicity of both enantiomers against L1210 murine leukemia and B16 murine melanoma cells grown in culture are reported and compared to racemate (±)-1. The natural (S)-(-)-enantiomer of 1 is more reactive with DNA and more cytotoxic than its unnatural mirror image and the racemic mixture.

Keywords: sequence specificity, cytotoxicity, DNA alkylation, CC1065, Duocarmycins

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2006
Page: [139 - 146]
Pages: 8
DOI: 10.2174/157340606776056188
Price: $58

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