Efficient Synthesis of Various Secondary Amines Through a Titanium(IV) isopropoxide-Mediated Reductive Amination of Ketones

Author(s): Chanaz Salmi, Yves Letourneux, Jean M. Brunel.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 5 , 2006

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Abstract:

An efficient method for the synthesis of various secondary amines through a titanium(IV)- isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and amines were involved leading to the expected products in moderate to excellent yields up to 98% in numerous cases. The mechanistic rationale of this reaction has been demonstrated through 1H and 13C NMR experiments and occurs exclusively via the formation of a transient imine species.

Keywords: Titanium, reductive amination, ketones, secondary amines, imines

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2006
Page: [396 - 401]
Pages: 6
DOI: 10.2174/157017806776611845
Price: $65

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