An efficient method for the synthesis of various secondary amines through a titanium(IV)- isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and amines were involved leading to the expected products in moderate to excellent yields up to 98% in numerous cases. The mechanistic rationale of this reaction has been demonstrated through 1H and 13C NMR experiments and occurs exclusively via the formation of a transient imine species.
Keywords: Titanium, reductive amination, ketones, secondary amines, imines
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