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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Efficient Synthesis of Various Secondary Amines Through a Titanium(IV) isopropoxide-Mediated Reductive Amination of Ketones

Author(s): Chanaz Salmi, Yves Letourneux and Jean M. Brunel

Volume 3, Issue 5, 2006

Page: [396 - 401] Pages: 6

DOI: 10.2174/157017806776611845

Price: $65

Abstract

An efficient method for the synthesis of various secondary amines through a titanium(IV)- isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and amines were involved leading to the expected products in moderate to excellent yields up to 98% in numerous cases. The mechanistic rationale of this reaction has been demonstrated through 1H and 13C NMR experiments and occurs exclusively via the formation of a transient imine species.

Keywords: Titanium, reductive amination, ketones, secondary amines, imines


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