Diastereoisomeric Synthesis of Novel Analogues of d4T having an Isochroman Glycon Moiety

Author(s): Christophe Len.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 1 , 2006

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1,2-O-Isopropylidene-α-D-xylofuranose has been used as a chiral protecting group of the formyl group of 2-bromobenzaldehyde, in which it acts as a resolving agent leading to separable diastereoisomers when a new stereocenter is created by substitution of bromine by a 2,3-dihydroxypropyl chain. These separated diastereoisomers were cyclised to furnish the target nucleoside analogues of d4T as an isochroman.

Keywords: d4T, isochroman, D-xylose

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Article Details

Year: 2006
Page: [42 - 44]
Pages: 3
DOI: 10.2174/157017806774964422

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