Prolinates as Secondary Amines in Aminocarbonylation: Synthesis of NAcylated Prolinates
Methyl prolinate and benzyl prolinate were used as secondary amine nucleophiles in palladium catalysed aminocarbonylation of iodo-aromatics and iodo-alkenes. A mixture of 2-oxo-carboxamide and carboxamide type derivatives or pure carboxamides can be obtained by using iodo-benzene or iodo-alkenes as substrates, respectively. The aminocarbonylation of iodo-alkenes in [bmim][PF6] ionic liquid was also carried out.
Keywords: Aminocarbonylation, carbon monoxide, proline, palladium, ionic liquid
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