Prolinates as Secondary Amines in Aminocarbonylation: Synthesis of NAcylated Prolinates

Author(s): Eszter Takacs , Rita Skoda-Foldes , Peter Acs , Erno Muller , George Kokotos , Laszlo Kollar .

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 1 , 2006

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Abstract:

Methyl prolinate and benzyl prolinate were used as secondary amine nucleophiles in palladium catalysed aminocarbonylation of iodo-aromatics and iodo-alkenes. A mixture of 2-oxo-carboxamide and carboxamide type derivatives or pure carboxamides can be obtained by using iodo-benzene or iodo-alkenes as substrates, respectively. The aminocarbonylation of iodo-alkenes in [bmim][PF6] ionic liquid was also carried out.

Keywords: Aminocarbonylation, carbon monoxide, proline, palladium, ionic liquid

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Article Details

VOLUME: 3
ISSUE: 1
Year: 2006
Page: [62 - 67]
Pages: 6
DOI: 10.2174/157017806774964431

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