Mastocytosis

Author(s): Tracy I. George.

Journal Name:Current Cancer Therapy Reviews

Volume 8 , Issue 1 , 2012

Abstract:

Mastocytosis or mast cell disease represents a clonal, neoplastic proliferation of mast cells that can present in one or multiple organs, varying from indolent to aggressive disorders in adult and pediatric patients. This review presents the definition of the various forms of mastocytosis along with the characteristic cytomorphological, immunophenotypic, cytogenetic, and molecular features and discusses in depth the differential diagnoses. Following this presentation, the review then focuses on therapeutic approaches, including targeted therapy.

Keywords: Mastocytosis, D816V KIT

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2012
Page: [35 - 43]
Pages: 9
DOI: 10.2174/157339412799462549