Current Cancer Therapy Reviews

Kurt S. Zaenker
Institute of Immunology and Experimental Oncology University Witten/Herdecke
Stockumerstraße 10, 58448 Witten
Germany

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Chronic Eosinophilic Leukemia, Not Otherwise Specified (CEL, NOS)

Author(s): Cherie H. Dunphy.

Abstract:

Chronic eosinophilic leukemia, NOS (CEL, NOS) is considered a myeloproliferative neoplasm and is defined as a clonal proliferation of eosinophil precursors. This review presents the definition and characteristic cytomorphological, immunophenotypic, cytogenetic, and molecular features of CEL, NOS and discusses in depth the differential diagnoses. Following this presentation, the review then focuses on therapeutic approaches, including targeted therapy.

Keywords: Chronic eosinophilic leukemia, idiopathic hypereosinophilia, clonality

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2012
Page: [30 - 34]
Pages: 5
DOI: 10.2174/157339412799462512