GCPII Imaging and Cancer
C. A. Foss, R. C. Mease, S. Y. Cho, H. J. Kim and M. G. Pomper
Affiliation: Johns Hopkins Medical School, 1550 Orleans Street, 492 CRB II, Baltimore, MD 21231, USA.
Glutamate carboxypeptidase II (GCPII) in the central nervous system is referred to as the prostate-specific membrane antigen (PSMA) in the periphery. PSMA serves as a target for imaging and treatment of prostate cancer and because of its expression in solid tumor neovasculature has the potential to be used in this regard for other malignancies as well. An overview of GCPII/PSMA in cancer, as well as a discussion of imaging and therapy of prostate cancer using a wide variety of PSMA-targeting agents is provided.
Keywords: Prostate-specific membrane antigen, PSMA, prostate cancer, molecular imaging, PET, SPECT, Glutamate carboxypeptidase II, malignancies, enzymatic activity, heterogeneous expression
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