Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions

Author(s): Masashi Kitazawa, Rodrigo Medeiros, Frank M. LaFerla.

Journal Name: Current Pharmaceutical Design

Volume 18 , Issue 8 , 2012

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Abstract:

Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies.

Keywords: Alzheimer disease, amyloid-beta, tau, transgenic mouse models, dementia, neurodegeneration, amyloid precursor protein (APP), mild cognitive impairment (MCI), synaptic dysfunction, mutations

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Article Details

VOLUME: 18
ISSUE: 8
Year: 2012
Page: [1131 - 1147]
Pages: 17
DOI: 10.2174/138161212799315786

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