Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

Back

Screening Strategies to Identify New Antibiotics

Author(s): Mark S. Butler, Matthew A. Cooper.

Abstract:

The emergence of multi-drug resistant bacteria is one of the most critical medical problems currently facing humankind, which will only get worse if no new antibacterial drugs are launched. This article will first review commonly used screening strategies used to identify potential new antibiotics and then discuss novel screening methods. In addition, new assays, methods, biological targets and compounds with novel modes of action undergoing pre-clinical or clinical development are briefly discussed.

Keywords: Antibiotics, drug resistance, biofilm, virulence, efflux, synergy, antisense, fragment based drug design, screening, mutants

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 13
ISSUE: 3
Year: 2012
Page: [373 - 387]
Pages: 15
DOI: 10.2174/138945012799424624
Price: $58