The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy

Author(s): L. E. Xodo, V. Rapozzi, M. Zacchigna, S. Drioli, S. Zorzet.

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 6 , 2012

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Abstract:

Pheophorbide a is a clorophyll catabolite that recently has drawn the attention of several investigators for its potential in photodynamic therapy. In this review we summarize its photophysical properties, phototoxicity, cellular localization, biodistribution and PDT activity as a free or conjugated molecule.

Keywords: Photodynamic therapy, Pheophorbide a, Photophysical parameters, Tissue distribution, Imaging, In vivo activity, clorophyll, phototoxicity, PDT activity, photochemical reaction

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Article Details

VOLUME: 19
ISSUE: 6
Year: 2012
Page: [799 - 807]
Pages: 9
DOI: 10.2174/092986712799034879
Price: $58

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