Targeting Nitrosative Stress for Neurovascular Protection: New Implications in Brain Diseases

Author(s): Rong-Rong Tao, Yue-Long Ji, Ying-Mei Lu, Kohji Fukunaga, Feng Han.

Journal Name: Current Drug Targets

Volume 13 , Issue 2 , 2012

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Abstract:

Nitric oxide/peroxynitrite signaling is associated with manifold neurovascular pathogenic cascades that lead to neurodegenerative diseases, including ischemic stroke, Alzheimers disease, and vascular dementia. Considerable evidence suggests that reactive nitrogen species as mediators of nitrosative stress could damage biomolecules and subsequently facilitate the breakdown of the highly-structured cellular machinery. Herein, we focus on nitrosative stress signaling, which is intimately associated with endothelial cell injury and blood-brain barrier damage in stroke and neurodegenerative diseases. Unraveling the detrimental role of nitrosative stress signaling in initiating and driving neurovascular pathogenesis may lead to the development of novel vasoprotective strategies via restorative therapies for brain diseases.

Keywords: Nitrosative stress, endothelium, blood-brain barrier, peroxynitrite, cerebral ischemia, vasoprotection, cerebrovascular disease, Alzheimer's disease, vascular dementia, parkinson disease

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2012
Page: [272 - 284]
Pages: 13
DOI: 10.2174/138945012799201649
Price: $58

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