Relevance of Dopamine D2/Neurotensin NTS1 and NMDA/Neurotensin NTS1 Receptor Interaction in Psychiatric and Neurodegenerative Disorders

Author(s): S. Tanganelli, T. Antonelli, M. C. Tomasini, S. Beggiato, K. Fuxe, L. Ferraro.

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 3 , 2012

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Abstract:

The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS1/D2 receptor interaction. More recently, neurochemical experiments also supported the existence of a possible interaction between NT and N-methyl-d-aspartate (NMDA) receptors. In particular, it has been suggested that NT, by amplifying NMDA receptor signaling, could be involved in neurodegeneration.

The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D2 or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.

Keywords: Neurotensin analogues, SR48692, NTS1 receptor, Antipsychotic drugs, Dopamine, Receptor heteromers, Microdialysis, Nucleus accumbens, Cerebral ischemia, Glutamate, Structure-activity relationship

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Article Details

VOLUME: 19
ISSUE: 3
Year: 2012
Page: [304 - 316]
Pages: 13
DOI: 10.2174/092986712803414268
Price: $58

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