Abstract
Spreading Depression is the underlying patho physiological mechanism for the neurological symptoms of migraine aura and is thought to play a major role in triggering migraine. Therefore it seems reasonable to use the Spreading Depression as a pharmacological tool for anti migraine drugs. Drugs that are able to alter parameters of Spreading Depression should also influence appearance and course of migraine attacks. Concerning the classification on the different mechanisms of drug action, especially the retinal Spreading Depression is useful, due to the separation of vascular and neuronal effects. In this study we investigated substances from different classes of common anti migraine drugs on different parameters of the retinal spreading depression. The results are discussed according to the classification of the drug.
Keywords: Retinal Spreading Depression, excitation depression waves, migraine, excitability, ASS, 5-CT, barbiturate, propranolol, topiramate, physiological
Current Medicinal Chemistry
Title: The Pharmacological Control of Neuronal Excitability in the Retinal Spreading Depression Model of Migraine
Volume: 19 Issue: 2
Author(s): M. Wiedemann, B. Lyhs, J. -P. Bartels and M. Sieber
Affiliation:
Keywords: Retinal Spreading Depression, excitation depression waves, migraine, excitability, ASS, 5-CT, barbiturate, propranolol, topiramate, physiological
Abstract: Spreading Depression is the underlying patho physiological mechanism for the neurological symptoms of migraine aura and is thought to play a major role in triggering migraine. Therefore it seems reasonable to use the Spreading Depression as a pharmacological tool for anti migraine drugs. Drugs that are able to alter parameters of Spreading Depression should also influence appearance and course of migraine attacks. Concerning the classification on the different mechanisms of drug action, especially the retinal Spreading Depression is useful, due to the separation of vascular and neuronal effects. In this study we investigated substances from different classes of common anti migraine drugs on different parameters of the retinal spreading depression. The results are discussed according to the classification of the drug.
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Cite this article as:
Wiedemann M., Lyhs B., -P. Bartels J. and Sieber M., The Pharmacological Control of Neuronal Excitability in the Retinal Spreading Depression Model of Migraine, Current Medicinal Chemistry 2012; 19 (2) . https://dx.doi.org/10.2174/092986712803414178
DOI https://dx.doi.org/10.2174/092986712803414178 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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