Natural Products: Promising Resources for Cancer Drug Discovery

Author(s): Susmita Mondal, Santu Bandyopadhyay, Mrinal K. Ghosh, Sibabrata Mukhopadhyay, Siddhartha Roy, Chitra Mandal.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 12 , Issue 1 , 2012

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Natural products are important sources of anti-cancer lead molecules. Many successful anti-cancer drugs are natural products or their analogues. Many more are under clinical trials. The present review focuses on chemopreventive and anti-cancer activities of polar and non-polar extracts, semi purified fractions and pure molecules from terrestrial plants of India reported between 2005 and 2010 emphasizing possible mechanisms of action of pure molecules.

Keywords: Apoptosis, Chemoprevention, Immunotherapy, Lead molecule, Medicinal plants, CHEMOTHERAPEUTIC, multi-cellular, Neaoplastic cells, Azadirchta Indica, metabolic engineering

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Article Details

Year: 2012
Page: [49 - 75]
Pages: 27
DOI: 10.2174/187152012798764697

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PDF: 161