Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Natural Products: Promising Resources for Cancer Drug Discovery

Author(s): Chitra Mandal, Siddhartha Roy, Sibabrata Mukhopadhyay, Mrinal K. Ghosh, Santu Bandyopadhyay, Susmita Mondal.

Abstract:

Natural products are important sources of anti-cancer lead molecules. Many successful anti-cancer drugs are natural products or their analogues. Many more are under clinical trials. The present review focuses on chemopreventive and anti-cancer activities of polar and non-polar extracts, semi purified fractions and pure molecules from terrestrial plants of India reported between 2005 and 2010 emphasizing possible mechanisms of action of pure molecules.

Keywords: Apoptosis, Chemoprevention, Immunotherapy, Lead molecule, Medicinal plants, CHEMOTHERAPEUTIC, multi-cellular, Neaoplastic cells, Azadirchta Indica, metabolic engineering

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2012
Page: [49 - 75]
Pages: 27
DOI: 10.2174/187152012798764697