Novel Targets for Malaria Therapy

Priyanka      Prabhu; Vandana      Patravale

Abstract

Malaria has emerged as one of the most debilitating parasitic infection with about 500 million cases reported annually and one million deaths worldwide. Currently, Plasmodium falciparum has developed resistance to almost all classes of antimalarials, thus precluding the use of those agents which once formed the cornerstone of malaria therapy. In lieu of this phenomenon, and taking into consideration the absence of an effective vaccine for malaria, the only way to combat the deadly parasite is to enrich the antimalarial cache with new molecules acting on fresh targets in the parasite. After potential targets have been validated, these targets can be used as basis for screening compounds to identify new leads followed by lead optimization. This review discusses novel targets of the malaria parasite that can be utilized to treat the disease.

Keywords: Glycolysis, hemoglobin, malaria, novel targets, nutrient uptake, proteases, permeability pathways, PfHT inhibitors, pnatothenate, erythrocyte