Metastasis Suppressors: Basic and Translational Advances

Author(s): C. Buchanan, M. A. Lago Huvelle, M. G. Peters.

Journal Name: Current Pharmaceutical Biotechnology

Volume 12 , Issue 11 , 2011

Abstract:

Tumor metastasis is a main contributor to death in cancer patients. In the last years, a new class of molecules that reduces the metastatic propensity has been identified: metastasis suppressors. These proteins regulate multiple steps in the metastatic cascade, including cell invasion, survival in the vascular and lymphatic circulation, and colonization of distant organ sites. As a consequence, they are very important therapeutic targets. This review discusses our current understanding of metastasis suppressors and how this knowledge might be useful to improve the treatment of cancer patients.

Keywords: Metastasis suppressor genes, metastatic cascade, suppressor-based therapies, cancer cell types, colonize ectopic tissue, metastatic process, Paget hypothesized, Innumerable oncogenes, amino acids, human genome, oral squamous cells, metastatic melanoma, Simpson-Golabi-Behmel syndrome (SGBS), micrometastatic tumor cells

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Article Details

VOLUME: 12
ISSUE: 11
Year: 2011
Page: [1948 - 1960]
Pages: 13
DOI: 10.2174/138920111798376914
Price: $58

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