Abstract
Flavonoids are new promising potential natural compounds for treating Alzheimers disease (AD). Actually most promising drugs for symptomatic treatment of AD are acetylcholinesterase inhibitors (AChEI). Flavonoids with AChE inhibitory activity and due to their well known antioxidant activity could be new multipotent drugs for AD treatment. This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE). Over, all this review refers to 128 flavonoids, which are classified in chemical structure, and summarizes 64 references.
Keywords: Acetylcholinesterase inhibitors, Alzheimer's disease, flavonoids, antioxidant activity, structure-activity relationship, natural products, flavones, flavanones, flavonols, isoflavones, chalcones
Current Medicinal Chemistry
Title: Flavonoids as Acetylcholinesterase Inhibitors
Volume: 18 Issue: 34
Author(s): I. Uriarte-Pueyo and M. I. Calvo
Affiliation:
Keywords: Acetylcholinesterase inhibitors, Alzheimer's disease, flavonoids, antioxidant activity, structure-activity relationship, natural products, flavones, flavanones, flavonols, isoflavones, chalcones
Abstract: Flavonoids are new promising potential natural compounds for treating Alzheimers disease (AD). Actually most promising drugs for symptomatic treatment of AD are acetylcholinesterase inhibitors (AChEI). Flavonoids with AChE inhibitory activity and due to their well known antioxidant activity could be new multipotent drugs for AD treatment. This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE). Over, all this review refers to 128 flavonoids, which are classified in chemical structure, and summarizes 64 references.
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Cite this article as:
Uriarte-Pueyo I. and I. Calvo M., Flavonoids as Acetylcholinesterase Inhibitors, Current Medicinal Chemistry 2011; 18 (34) . https://dx.doi.org/10.2174/092986711798184325
DOI https://dx.doi.org/10.2174/092986711798184325 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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