Flavonoids as Acetylcholinesterase Inhibitors

Author(s): I. Uriarte-Pueyo , M. I. Calvo .

Journal Name: Current Medicinal Chemistry

Volume 18 , Issue 34 , 2011


Flavonoids are new promising potential natural compounds for treating Alzheimers disease (AD). Actually most promising drugs for symptomatic treatment of AD are acetylcholinesterase inhibitors (AChEI). Flavonoids with AChE inhibitory activity and due to their well known antioxidant activity could be new multipotent drugs for AD treatment. This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE). Over, all this review refers to 128 flavonoids, which are classified in chemical structure, and summarizes 64 references.

Keywords: Acetylcholinesterase inhibitors, Alzheimer's disease, flavonoids, antioxidant activity, structure-activity relationship, natural products, flavones, flavanones, flavonols, isoflavones, chalcones

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Article Details

Year: 2011
Page: [5289 - 5302]
Pages: 14
DOI: 10.2174/092986711798184325
Price: $58

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PDF: 44