HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis and anti-apoptosis, lifespan extension, antioxidation and so on. In recent years, studies show that HSP22 plays a crucial role in many neurological diseases, such as hereditary nerve endings disease, Alzheimer disease and Charco-Marie-Tooth. This review explores the progress in HSP22 and its involvement in human neurological disease.
Keywords: HSP22, chaperone activity, protein-kinase, apoptosis, interaction, neurological disease, alpha-crystallin domain, autoimmune diseases, Hela cells, Trimerization, polyglutamine disease, chromatography, ultracentrifugation, immunocomplexes, ATP-dependent chaperones, Drosophila
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