Abstract
HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis and anti-apoptosis, lifespan extension, antioxidation and so on. In recent years, studies show that HSP22 plays a crucial role in many neurological diseases, such as hereditary nerve endings disease, Alzheimer disease and Charco-Marie-Tooth. This review explores the progress in HSP22 and its involvement in human neurological disease.
Keywords: HSP22, chaperone activity, protein-kinase, apoptosis, interaction, neurological disease, alpha-crystallin domain, autoimmune diseases, Hela cells, Trimerization, polyglutamine disease, chromatography, ultracentrifugation, immunocomplexes, ATP-dependent chaperones, Drosophila
Current Neurovascular Research
Title: HSP22 and its Role in Human Neurological Disease
Volume: 8 Issue: 4
Author(s): Xiaomei Guan, Chao Tu, Mengjun Li and Zhiping Hu
Affiliation:
Keywords: HSP22, chaperone activity, protein-kinase, apoptosis, interaction, neurological disease, alpha-crystallin domain, autoimmune diseases, Hela cells, Trimerization, polyglutamine disease, chromatography, ultracentrifugation, immunocomplexes, ATP-dependent chaperones, Drosophila
Abstract: HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis and anti-apoptosis, lifespan extension, antioxidation and so on. In recent years, studies show that HSP22 plays a crucial role in many neurological diseases, such as hereditary nerve endings disease, Alzheimer disease and Charco-Marie-Tooth. This review explores the progress in HSP22 and its involvement in human neurological disease.
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Cite this article as:
Guan Xiaomei, Tu Chao, Li Mengjun and Hu Zhiping, HSP22 and its Role in Human Neurological Disease, Current Neurovascular Research 2011; 8 (4) . https://dx.doi.org/10.2174/156720211798121034
DOI https://dx.doi.org/10.2174/156720211798121034 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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