Abstract
HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis and anti-apoptosis, lifespan extension, antioxidation and so on. In recent years, studies show that HSP22 plays a crucial role in many neurological diseases, such as hereditary nerve endings disease, Alzheimer disease and Charco-Marie-Tooth. This review explores the progress in HSP22 and its involvement in human neurological disease.
Keywords: HSP22, chaperone activity, protein-kinase, apoptosis, interaction, neurological disease, alpha-crystallin domain, autoimmune diseases, Hela cells, Trimerization, polyglutamine disease, chromatography, ultracentrifugation, immunocomplexes, ATP-dependent chaperones, Drosophila
Current Neurovascular Research
Title: HSP22 and its Role in Human Neurological Disease
Volume: 8 Issue: 4
Author(s): Xiaomei Guan, Chao Tu, Mengjun Li and Zhiping Hu
Affiliation:
Keywords: HSP22, chaperone activity, protein-kinase, apoptosis, interaction, neurological disease, alpha-crystallin domain, autoimmune diseases, Hela cells, Trimerization, polyglutamine disease, chromatography, ultracentrifugation, immunocomplexes, ATP-dependent chaperones, Drosophila
Abstract: HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis and anti-apoptosis, lifespan extension, antioxidation and so on. In recent years, studies show that HSP22 plays a crucial role in many neurological diseases, such as hereditary nerve endings disease, Alzheimer disease and Charco-Marie-Tooth. This review explores the progress in HSP22 and its involvement in human neurological disease.
Export Options
About this article
Cite this article as:
Guan Xiaomei, Tu Chao, Li Mengjun and Hu Zhiping, HSP22 and its Role in Human Neurological Disease, Current Neurovascular Research 2011; 8 (4) . https://dx.doi.org/10.2174/156720211798121034
DOI https://dx.doi.org/10.2174/156720211798121034 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-tumoral Properties of Endogenous Angiogenesis Inhibitors: A Case for Continued TIMP-2 Preclinical Development
Current Angiogenesis (Discontinued) The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a Bystander than a Player?
Current Vascular Pharmacology Metabolism-based Drug-drug Interactions in Patients with Chronic Respiratory Diseases: A Review Focusing on Drugs Affecting the Respiratory System
Current Drug Metabolism Genetically Modified Viruses Vaccines by Design
Current Pharmaceutical Biotechnology Oxidative Stress and Endothelial Dysfunction in Cardiovascular Disease: Mitochondria-Targeted Therapeutics
Current Medicinal Chemistry Intra and Extracellular Protein Interactions with Tau
Current Alzheimer Research Chemical and Pharmacological Aspects of Heteroaryl-Nitrones
Current Medicinal Chemistry Longitudinal Functional MRI of Motor and Cognitive Recovery Following Stroke: A Review
Current Medical Imaging Regulation of P2X3 Receptor Structure and Function
CNS & Neurological Disorders - Drug Targets Technological Advances in Antigen Delivery and Synthetic Peptide Vaccine Developmental Strategies
Mini-Reviews in Medicinal Chemistry Mitochondria Sentencing About Cellular Life and Death: A Matter of Oxidative Stress
Current Pharmaceutical Design The Classic Basic Protein of Myelin – Conserved Structural Motifs and the Dynamic Molecular Barcode Involved in Membrane Adhesion and Protein-Protein Interactions
Current Protein & Peptide Science H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma
Current Molecular Pharmacology Melatonin Decreases Levels of S100β and NFκB, Increases Levels of Synaptophysinina Rat Model of Alzheimer's Disease
Current Aging Science Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Local Activation and Systemic Dysregulation of T Lymphocytes in Sjögren’s Syndrome
Current Pharmaceutical Biotechnology Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies
Medicinal Chemistry Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice
Current Neuropharmacology Patent Selections
Recent Patents on Regenerative Medicine D-Hormone Derivatives for the Treatment of Osteoporosis: From Alfacalcidol to Eldecalcitol
Mini-Reviews in Medicinal Chemistry