Thiourea-Catalyzed Asymmetric Mannich-Type Reactions

Author(s): Bo Han, Jun-Long Li, You-Cai Xiao, Si-Li Zhou, Ying-Chun Chen.

Journal Name: Current Organic Chemistry

Volume 15 , Issue 24 , 2011

Abstract:

Asymmetric Mannich-type reactions are important organic transformations that provide excellent protocols for the synthesis of optically active nitrogen-containing compounds. This article provides an overview on the development of thiourea-catalyzed asymmetric Mannich or nitro-Mannich reactions including scope, limitations, and applications of different catalytic systems.

Keywords: Thiourea, Mannich-type reaction, asymmetric catalysis, organocatalysis, organocatalytic, organic chemistry, stereoselective catalysis, hydrogen-bonding donors, monothiourea, bis-thiourea, b-amino acids, Lewis basic, Isoquinolines, Wittig Reaction, Nitro-Mannich

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Article Details

VOLUME: 15
ISSUE: 24
Year: 2011
Page: [4128 - 4143]
Pages: 16
DOI: 10.2174/138527211798109204
Price: $58

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