Current Genomics

Christian Néri
Institute of Biology Paris-Seine
CNRS UMR 8256 and UPMC
Paris, 75005


The Shock of the New: Progress in Schizophrenia Genomics

Author(s): Susan Moore, Eric Kelleher and Aiden Corvin

Affiliation: Dept. of Psychiatry, Trinity Centre for Health Sciences, St. James' Hospital, Dublin 8, Ireland.


A growing list of common and rare genetic risk variants are being implicated in schizophrenia susceptibility. As with other complex genetic disorders most of the variance in genetic risk is still to be attributed. What can be learned from progress to date? The available data challenges how we conceptualize schizophrenia and suggests strong aetiological links with other psychiatric and developmental disorders. With the identification of rare copy number risk variants implicating specific genes (e.g. VIPR2 and NRXN1) it is increasingly possible to investigate molecular aetiology in patient subgroups to establish whether schizophrenia represents one or many different disease processes. This review summarizes recent research progress and suggests how the tools of modern genomics and neuroscience can be applied to best understand this devastating disorder.

Keywords: Copy Number Variation, DNA variants, neurodevelopmental disorders, psychosis, schizophrenia, GWAS, MHC, PHENOTYPE, psychiatric disorders, Variants

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Article Details

Page: [516 - 524]
Pages: 9
DOI: 10.2174/138920211797904089
Price: $58