The Role of Chemokines, Cytokines and Adhesion Molecules in Stem Cell Trafficking and Homing

Author(s): Y. Cui, P. Madeddu.

Journal Name: Current Pharmaceutical Design

Volume 17 , Issue 30 , 2011

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Abstract:

Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.

Keywords: Stem cells, cardiovascular disease, ischemia, homing, signalling, repair, endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), chemokine, proteases

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Article Details

VOLUME: 17
ISSUE: 30
Year: 2011
Page: [3271 - 3279]
Pages: 9
DOI: 10.2174/138161211797904109
Price: $58

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