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Current Diabetes Reviews
ISSN (Print): 1573-3998
ISSN (Online): 1875-6417
DOI: 10.2174/157339911797579205      Price:  $58

Diabetes and Periodontal Diseases: Interplay and Links

Author(s): Flavia Lakschevitz, Guy Aboodi, Howard Tenenbaum and Michael Glogauer
Pages 433-439 (7)
The association between diabetes and periodontal diseases is well-established. Diabetes is a risk factor for periodontal disease, with diabetic patients exhibiting an increased prevalence, extent and severity of gingivitis and perio- dontitis compared to healthy adults. Several mechanisms involved in the pathogenesis of diabetes have also been associated with periodontal disease progression. It is recognized today that there is a bidirectional relationship between diabetes and periodontal disease, with recent research showing that periodontal disease may affect the metabolic control of diabetes in diabetic patients.

In this review, we present the current knowledge of the interplay between periodontal diseases and diabetes through the evaluation of randomized control and longitudinal cohort studies published in the past 15 years. Current data support the conclusion that diabetic patients are at increased risk for periodontal diseases, and that patients with poorly controlled diabetes are at risk for severe periodontitis. This results in the destruction of oral connective tissue and generalized bone loss, leading ultimately to tooth loss. Although the effect of periodontal disease on glycemic control in type 1 diabetic patients is controversial, evidence does show a direct correlation between periodontal health and glycemic control in type 2 diabetic patients. Furthermore, several studies have demonstrated the beneficial effect of periodontal treatment on metabolic control of type 2 diabetic patients.

Glycemic control, metabolic control, Periodontal Diseases, Type 1 Diabetes, Type 2 Diabetes, TNF-alpha, IL-1b, Leukocyte Adhesion Deficiency, Neutrophils, HbA1c
Matrix Dynamics Group, University of Toronto, Faculty of Dentistry, Room 221 Fitzgerald Building, 150 College Street, Toronto, Ontario M5S 3E2, Canada.