Quinazolinone Analogs as Potential Therapeutic Agents

Author(s): P. C. Sharma, G. Kaur, R. Pahwa, A. Sharma, H. Rajak.

Journal Name: Current Medicinal Chemistry

Volume 18 , Issue 31 , 2011

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Abstract:

Quinazolinone scaffold has been considered as a magic moiety possessing myriad spectrum of medicinal activities. Diversity of biological response profile has attracted considerable interest of several researchers across the globe to explore this skeleton for its assorted therapeutic significance. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, CNS depressant, antiinflammatory, antihistaminic, anticancer and so on. Moreover, the nucleus constitutes an integral structural component in a number of drugs currently employed in several clinical therapies. The present paper is an earnest attempt to provide an insight view on the current medicinal aspects of quinazolinone heterocycles alongwith brief discussion of their chemistry.

Keywords: Heterocycles, pharmacological significance, quinazolinone, scaffold, assorted therapeutic, antibacterial, antifungal, anticonvulsant

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Article Details

VOLUME: 18
ISSUE: 31
Year: 2011
Page: [4786 - 4812]
Pages: 27
DOI: 10.2174/092986711797535326
Price: $58

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