Current Hypertension Reviews

Prof. Kazuomi Kario
Jichi Medical University
School of Medicine
Tochigi
Japan

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Role of the Autonomic Nervous System in the Endothelial Dysfunction of the Metabolic Syndrome

Author(s): Patricio Lopez-Jaramillo, Dora Ines Molina, Alba Aguillon, Diego Gomez-Arbelaez, Aristides Sotomayor-Rubio, Jose Lopez-Lopez.

Abstract:

In the last decade there has been an accelerated growth in the prevalence of metabolic syndrome (MS), especially in Latin American countries, which has led an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (DM2). Recently has been raised the relationship between the autonomic nervous system (ANS), endothelial dysfunction (ED) and the appearance of MS. In the present article we review the evidence that support the proposal that abdominal obesity (AO) produce adypokines that result in insulin resistance and low degree inflammation, which increase the activity of ANS, causing vasoconstriction, hypertension, decreased peripheral glucose uptake, and decreased secretion of insulin, leading to hyperglycemia and increased lipolysis and hypertriglyceridemia. All these factors cause ED, explaining the higher risk of the patients with MS of developing DM2 and CVD.

Keywords: Metabolic syndrome, endothelial dysfunction, autonomic nervous system, low degree inflammation, insulin resistance, preeclampsia, myocardial infarction, adipose tissue

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2011
Page: [73 - 79]
Pages: 7
DOI: 10.2174/157340211797457944
Price: $58