Pd-catalyzed α-Arylation of Carbonyl and Related Compounds: Recent Developments and Perspectives

Author(s): Petr Novak , Ruben Martin .

Journal Name: Current Organic Chemistry

Volume 15 , Issue 18 , 2011

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Abstract:

The palladium-catalyzed α-arylation of carbonyl-type compounds is a relatively emerging field within the cross-coupling arena. In recent years, these processes have experienced an exponential growth, particularly in the development of enantioselective variants of these reactions. Beyond any reasonable doubt, palladium-catalyzed α-arylation reactions represent a straightforward alternative to the classical synthesis of α-aryl carbonyl-type compounds that oftentimes involves time-consuming and economically inefficient steps. This review summarizes the last developments in the last 5 years, hence providing a general overview of the current state of the art for palladium-catalyzed α-arylation processes.

Keywords: Arylation, palladium, catalyst, carbonyl, ligand, phosphine, carbene, selectivity, -arylation of Ketones, Silyl Enol Ethers, Enantioselective, multi-heteroaromatic, XPhos ligand, Imines, carbene design

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Article Details

VOLUME: 15
ISSUE: 18
Year: 2011
Page: [3233 - 3262]
Pages: 30
DOI: 10.2174/138527211797248021
Price: $58

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