The Principle and the Potential Approach to ROS-dependent Cytotoxicity by Non-pharmaceutical Therapies: Optimal Use of Medical Gases with Antioxidant Properties

Title: The Principle and the Potential Approach to ROS-dependent Cytotoxicity by Non-pharmaceutical Therapies: Optimal Use of Medical Gases with Antioxidant Properties

Volume: 17 Issue: 22

Author(s): Mami Noda, Kyota Fujita, Chih-Hung Lee and Tohru Yoshioka

Affiliation:

Keywords: Hydrogen, medical gasses, oxidative stress, antioxidant, photosensitizer, hemoglobin, Singlet oxygen, transition metal ions, reperfusion, bilirubin

Abstract: Regulation of cellular redox balances is important for the homeostasis of human health. Thus, many important human diseases, such as inflammation, diabetes, glaucoma, cancers, ischemia and neurodegenerative diseases, have been investigated in the field of reactive oxygen species (ROS) and oxidative stress. To overcome the harmful effect of oxidative stress and ROS, one can directly eliminate them by medical gases such as carbon monoxide (CO), hydrogen sulphide (H2S), and molecular hydrogen (H2), or one can induce ROSresistant proteins and antioxidant enzymes to antagonize oxidative stresses. This article reviews the molecular mechanisms how these medical gasses work as antioxidants, and how ROS resistant proteins are produced in the physiological context. Targeted therapeutic modalities to scavenge or prevent ROS might be applied in the prevention and treatment of ROS-related diseases in the near future.

Cite this article as:

Noda Mami, Fujita Kyota, Lee Chih-Hung and Yoshioka Tohru, The Principle and the Potential Approach to ROS-dependent Cytotoxicity by Non-pharmaceutical Therapies: Optimal Use of Medical Gases with Antioxidant Properties, Current Pharmaceutical Design 2011; 17 (22) . https://dx.doi.org/10.2174/138161211797052600