Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge


Recent Progresses on AI-2 Bacterial Quorum Sensing Inhibitors

Author(s): Peng Zhu and Minyong Li

Affiliation: Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China.


Quorum sensing (QS) is a communication procedure that predominates gene expression in response to cell density and fluctuations in the neighboring environment as a result of discerning molecules termed autoinducers (AIs). It has been embroiled that QS can govern bacterial behaviors such as the secretion of virulence factors, biofilm formation, bioluminescence production, conjugation, sporulation and swarming motility. Autoinducer 2 (AI-2), a QS signaling molecule brought up to be involved in interspecies communication, exists in both gram-negative and -positive bacteria. Therefore, novel approaches to interrupt AI-2 quorum sensing are being recognized as next generation antimicrobials. In the present review article, we summarized recent progresses on AI-2 bacterial quorum sensing inhibitors and discussed their potential as the antibacterial agents.

Keywords: AI-2, bacteria, inhibitors, LuxP, LuxS, quorum sensing, bioluminescence, predominates gene expression, antibacterial agents, autoinducers

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Article Details

Page: [174 - 186]
Pages: 13
DOI: 10.2174/092986712803414187
Price: $58