Abstract
The last two decades have been crucial for neurooncology due to the enormous progress in the base research and in the medical technology. Such a continuous development has significantly improved the knowledge on the genetics and molecular biology of brain tumors, thus allowing to better define their prognosis and to find new therapeutic targets. Furthermore, it has provided sophisticated diagnostic and therapeutic tools that have radically changed the behavior of neurosurgeons, neurooncologists, and radiotherapists with regards to these neoplasms. Once considered rare and poorly treatable, infantile brain tumors (IBTs) are currently more and more diagnosed and benefit of the aforementioned progresses so that their prognosis has become quite similar to that of the older ages. The aim of the present paper is to review the factors that favored these advances and to analyze the main aspects concerning IBTs, namely: Current information on epidemiology and etiology; - Advances in the neuroimaging; - Changes in the surgical attitude; - Development of ad hoc chemotherapic and radiotherapic protocols; - The role of pathology and molecular biology in the prognosis; - Outcome; - Future directions.
Keywords: Infantile brain tumor, intracranial neoplasm, neuroimaging, molecular biology
Current Cancer Therapy Reviews
Title: Advances in the Management of Brain Tumors in Infants
Volume: 7 Issue: 3
Author(s): Luca Massimi, Benedetta Pettorini, Gianpiero Tamburrini, Massimo Caldarelli and Concezio Di Rocco
Affiliation:
Keywords: Infantile brain tumor, intracranial neoplasm, neuroimaging, molecular biology
Abstract: The last two decades have been crucial for neurooncology due to the enormous progress in the base research and in the medical technology. Such a continuous development has significantly improved the knowledge on the genetics and molecular biology of brain tumors, thus allowing to better define their prognosis and to find new therapeutic targets. Furthermore, it has provided sophisticated diagnostic and therapeutic tools that have radically changed the behavior of neurosurgeons, neurooncologists, and radiotherapists with regards to these neoplasms. Once considered rare and poorly treatable, infantile brain tumors (IBTs) are currently more and more diagnosed and benefit of the aforementioned progresses so that their prognosis has become quite similar to that of the older ages. The aim of the present paper is to review the factors that favored these advances and to analyze the main aspects concerning IBTs, namely: Current information on epidemiology and etiology; - Advances in the neuroimaging; - Changes in the surgical attitude; - Development of ad hoc chemotherapic and radiotherapic protocols; - The role of pathology and molecular biology in the prognosis; - Outcome; - Future directions.
Export Options
About this article
Cite this article as:
Massimi Luca, Pettorini Benedetta, Tamburrini Gianpiero, Caldarelli Massimo and Di Rocco Concezio, Advances in the Management of Brain Tumors in Infants, Current Cancer Therapy Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339411796234933
DOI https://dx.doi.org/10.2174/157339411796234933 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Catechol-O-Methyltransferase (COMT)-Mediated Methylation Metabolism of Endogenous Bioactive Catechols and Modulation by Endobiotics and Xenobiotics: Importance in Pathophysiology and Pathogenesis
Current Drug Metabolism Focal Adhesion Kinase: From In Vitro Studies to Functional Analyses In Vivo
Current Protein & Peptide Science Poly(ADP-Ribose) Polymerase Inhibitors: New Pharmacological Functions and Potential Clinical Implications
Current Pharmaceutical Design Molecular and Biochemical Changes of the Cardiovascular System due to Smoking Exposure
Current Pharmaceutical Design The Role of Aryl Hydrocarbon Receptor-Regulated Cytochrome P450 Enzymes in Glioma
Current Pharmaceutical Design Cucurbitacin E, An Experimental Lead Triterpenoid with Anticancer, Immunomodulatory and Novel Effects Against Degenerative Diseases. A Mini-Review
Current Topics in Medicinal Chemistry Structure-Function Relationship of Thiazolides, a Novel Class of Anti-Parasitic Drugs, Investigated in Intracellular and Extracellular Protozoan Parasites and Larval-Stage Cestodes
Anti-Infective Agents in Medicinal Chemistry Overview of Prostate Biomarkers as Potential Targets for Immunotherapy
Current Cancer Therapy Reviews Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy
Current Pharmaceutical Design Inducible Nitric Oxide Synthase-Vascular Endothelial Growth Factor Axis: A Potential Target to Inhibit Tumor Angiogenesis by Dietary Agents
Current Cancer Drug Targets LPS/TLR4 Pathways in Breast Cancer: Insights into Cell Signalling
Current Medicinal Chemistry Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer
Current Drug Delivery Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy
Current Pharmaceutical Design Isolation, Purification and Characterization of a Novel Steroidal Saponin Cholestanol Glucoside from Lasiodiplodia theobromae that Induces Apoptosis in A549 Cells
Anti-Cancer Agents in Medicinal Chemistry Perspectives on Chemopreventive and Therapeutic Potential of Curcumin Analogs in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation
Current Molecular Medicine Type 2 Diabetes Mellitus and Invokana: An FDA Approved Drug
Current Diabetes Reviews Impact of Inhibitors of the Renin-Angiotensin-Aldosterone System on Liver Fibrosis and Portal Hypertension
Current Medicinal Chemistry Neuroprotective Mechanisms of Oxygen and Ethanol: A Potential Combination Therapy in Stroke
Current Medicinal Chemistry Properties of Cell Sources in Tissue-Engineered Three-dimensional Oral Mucosa Model: A Review
Current Stem Cell Research & Therapy