The transdermal drug delivery system (TDDS) acts as a substitute for oral route as well as parentral route as it avoids the limitation of conventional dosage forms like avoidance of hepatic first pass metabolism, reduced side effects and can deliver the drug at a predetermined rate over a prolonged period of time. It also avoids the discomfort associated with the parenteral therapy and improves patient compliance. This review covers types of transdermal drug delivery system, factors affecting TDDS, mechanism of action of TDDS, evaluation parameters for TDDS and various recent marketed products.
Keywords: Transdermal drug delivery (TDDS), iontophoresis, electroporation, evaluation of transdermal delivery, Single-layer Drug-in-Adhesive, parenteral therapy, Multi-layer Drug-in-Adhesive, Drug Reservoir-in-Adhesive, Drug Matrix-in-Adhesive
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